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St. Luke’s University Health Network operates 15 campuses and more than 300 outpatient sites, managing over 2.5 petabytes of patient data and 23,000 employees across a high-value cyberattack target. The network deployed Microsoft Security Copilot as an AI layer connecting its existing Defender, Sentinel, Entra, Purview, and Intune stack to unify threat visibility and automate phishing triage. Security Copilot agents now save nearly 200 hours monthly by autonomously closing thousands of false-positive alerts, while incident reports that once took hours are generated in minutes.